Dodecagonal photonic crystal fibers (PCFs) filled with organic materials like propanol, butanol and ethanol have investigated. Intention is to study the behaviour of light in alcoholic groups. Propanol filled structure reports negative dispersion with high birefringence. Besides ethanol and butanol filled structure reports zero dispersion at communication wavelength. The overall birefringence reported is of order 10−3. The simulated structure has confinement loss of the order of 10−6 which is very low. Besides other properties like effective mode area, normalized frequency have also been studied.