The removal of Cr(VI) from aqueous solution by a novel Swietenia Mahogani fruit shell physically activated carbon (SMFS-PAC) was examined in a packed bed column study. The effects of significant parameters such as feed flow rate, bed depth, and initial Cr(VI) concentration were studied. Column data obtained at different conditions were described using the Thomas, Bed depth service time (BDST), Adams–Bohart, and Yoon–Nelson model in order to predict the breakthrough curves and to evaluate the model parameters of the packed bed column studies data. Among the models used, Thomas, BDST, and Yoon–Nelson model, respectively, fitted to the experimental data very well. The SMFS-PAC column study states the value of the good adsorption capacity for the removal of Cr(VI) from aqueous solution.