Since the enactment of the Clean Water Act (1972), which was supplemented by increased accountability under Resource Conservation and Recovery Act (RCRA) Subtitle D (1991) and the Clean Air Act Amendments (1996), landfills have indeed been widely used all around the world for treating various wastes. The landfill’s biological and biogeochemical processes are believed to be originated about 2 to 4 decades ago. Scopus and web of Science based bibliometric study reveals that there are few papers available in scientific domain. Further, till today not a single paper demonstrated the detailed landfills heterogenicity, chemistry and microbiological processes and their associated dynamics in a combined approach. Accordingly, the paper addresses the recent applications of cutting-edge biogeochemical and biological methods adopted by different countries to sketch an emerging perspective of landfill biological and biogeochemical reactions and dynamics. Additionally, the significance of several regulatory factors controlling the landfill’s biogeochemical and biological processes is highlighted. Finally, this article emphasizes the future opportunities for integrating advanced techniques to explain landfill chemistry explicitly. In conclusion, this paper will provide a comprehensive vision of the diverse dimensions of landfill biological and biogeochemical reactions and dynamics to the scientific world and policymakers.