Mesoporous metallic nanomaterials possess high surface area and abundant three- dimensional channel structure for efficient transport of reactants, which are attractive for catalysis applications. In this work, we report a ternary PtPdCo mesoporous nanospheres (MNs), developed by a soft template-assisted method, as an efficient electrocatalyst for methanol oxidation reaction (MOR). The physicochemical characterizations demonstrate that PtPdCo MNs possess abundant mesoporous channels, nanospheres assembly of tiny nanoparticles, and strong interatomic interaction and synergistic effect. Electrochemical test shows that this unique metal alloy brings superior MOR catalytic performance. The mass activity (MA) and specific activity (SA) of PtPdCo MNs are 2.05 A mgPt−1 and 3.31 mA cm−2 respectively, which are 3.87/3.8 times of commercial PtRu/C, 4.27/4.47 times of commercial Pt/C. In addition, the measurements of i-t (3600 s) and ADT (2000 cycles) further revealed the superior durability of the PtPdCo MNs. These results indicate PtPdCo MNs outperform to reported benchmark catalysts and this study represents a novel approach to reducing Pt costs while achieving high MOR performance.