Psychological well-being is crucial for university students facing academic and personal challenges. This study explores how hope and self-efficacy mediate the link between cognitive flexibility and psychological well-being in 302 SRM University students (aged 18–25). Standardized tools assessed psychological well-being (Warwick-Edinburgh Scale), cognitive flexibility (Dennis & Vander Wal, 2010), hope (Snyder et al., 1991), and self-efficacy (Sud et al., 2002). Results showed significant positive correlations between cognitive flexibility, hope, self-efficacy, and psychological well-being. Regression analysis indicated these factors predicted 26.2% of psychological well-being variance. Mediation analysis revealed hope and self-efficacy partially mediated the cognitive flexibility-psychological well-being rela-tionship, highlighting the importance of fostering cognitive adaptability, motivation, and self-confidence to enhance student mental well-being.