Herzog, Hibi, and Zheng classified the Cohen-Macaulay edge ideals of chordal graphs. In this paper, we classify Cohen-Macaulay edge ideals of (vertex) weighted oriented chordal and simplicial graphs, a more general class of monomial ideals. In particular, we show that the Cohen-Macaulay property of these ideals is equivalent to the unmixed one and hence, independent of the underlying field.