Cobalt-catalyzed hydroarylative cyclization of 1,6-enynes with aromatic ketones and esters via C-H activation

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Cobalt-catalyzed hydroarylative cyclization of 1,6-enynes with aromatic ketones and esters via C-H activation

Author : Dr. S. Mannathan

Year : 2014

Publisher : American Chemical Societyservice@acs.org

Source Title : Organic Letters

Document Type :

Abstract

A highly chemo- and stereoselective cobalt-catalyzed hydroarylative cyclization of 1,6-enynes with aromatic ketones and esters to synthesize functionalized pyrrolidines and dihydrofurans is described. A mechanism involving cobaltacycle triggered C-H activation of aromatic ketones and esters was proposed. © 2014 American Chemical Society.