An Effective Centrality-Based Community Detection Approach Using scRNA-Seq Data for Critical Neuro-Degenerative Diseases

Publications

An Effective Centrality-Based Community Detection Approach Using scRNA-Seq Data for Critical Neuro-Degenerative Diseases

Year : 2023

Publisher : Springer Science and Business Media Deutschland GmbH

Source Title : Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

Document Type :

Abstract

The process of community detection in a network uncovers groups of closely connected nodes, known as communities. In the context of gene correlation networks and neuro-degenerative diseases, this study introduces a systematic pipeline for centrality-based community detection using scRNA-Seq data. Comparisons with existing methods demonstrate its superior performance in terms of modularity. Furthermore, the resulting communities undergo biological validation and hub-gene analysis, which reveal disease-specific pathways and gene ontology associated with the genes within these communities.