We investigate Demailly’s Conjecture for a general set of sufficiently many points. Demailly’s Conjecture generalizes Chudnovsky’s Conjecture in providing a lower bound for the Waldschmidt constant of a set of points in projective space. We also study a containment between symbolic and ordinary powers conjectured by Harbourne and Huneke that in particular implies Demailly’s bound, and prove that a general version of this containment holds for generic determinantal ideals and defining ideals of star configurations.