Dual functionality of phosphonic acid appended phthalocyanines: inhibitors of urokinase plasminogen activator and anticancer photodynamic agents,

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Dual functionality of phosphonic acid appended phthalocyanines: inhibitors of urokinase plasminogen activator and anticancer photodynamic agents,

Dual functionality of phosphonic acid appended phthalocyanines: inhibitors of urokinase plasminogen activator and anticancer photodynamic agents,

Year : 2015

Publisher : RSC

Source Title : Chem. Commun

Document Type :

Abstract

Phthalocyanines (Pcs) bearing phosphonic acid groups at the periphery exhibit a potential photodynamic effect to induce phototoxicity on human bladder cancer epithelial cells (UM-UC-3). In vitro photophysical and biological studies show high intrinsic ability to inhibit the activity of urokinase plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9).