Together with a human-centered approach to designing and operating production and logistics in an industrial context, digital technologies can lead to a sustainable, resilient, and human-centric Industry 5.0 (I5.0). This article is one of the first interdisciplinary studies integrating digital technologies and circular economy (CE) concepts in I5.0. Using expert-based surveys of industry leaders and analytical hierarchical process techniques, the article advances CE and technology management by empirically investigating the influence of I5.0 on CE aspects in manufacturing. The novel results presented here can enable policymakers and industry leaders to design effective CE strategies.