This paper details the design and implementation of SoC’s UART-SPI Interface. The UART-SPI interface provides usage for the universal asynchronous receiver/transmitter (UART) to serial peripheral interface (SPI). This interface can be used to communicate to SPI slave devices from a PC with UART port. The interface consists of three blocks: the UART interface, the UART-to-SPI interfacing block and the SPI Master interface. © 2012 IEEE.