Phytochemicals are found to have enormous therapeutic potential and have been under investigation for the treatment of a variety of diseases for several years now. However, they suffer from various inherent limitations, such as poor solubility, low stability, poor bioavailability, and low gastric stability upon oral dosage. To overcome the aforementioned limitations, the phytochemicals are essentially encapsulated inside materials of choice, typically in nano, micro, or other formulations to improve their efficacy and bioavailability. This chapter begins by elaborating on the various material fabrication strategies reported for the synthesis of phytochemicals-incorporated nanoparticles, microparticles, liposomes, nanofibers, hydrogels, polymeric patches, and scaffolds, and their biomedical applications are also discussed. Moreover, this chapter also covers the recent advancements in the field of phytochemicals-based formulations such as 3D printed formulations, microneedles-based implants, and finally plant-derived exosomes, which are natural lipid-based nanovesicles that have excellent biomedical applications.