Contamination, pollution and degradation of air, water, and soil environments by geogenically and anthropogenically generated various pollutants are severe and life threatening problems globally. Recently, bioremediation has evolved as the most promising eco-friendly approach in the field of environmental remediation technology, playing a pivotal role in solving the menacing problems of environmental pollution in 2018. Several innovative and advanced bioremediation technologies have been developed using genomics and metagenomics, proteomics, transcriptomics and metabolomics in order to overcome the limitations concerning the process. The present chapter has attempted to briefly discuss the advancement of bioremediation in respect to significant biotechnological improvement for applying as green technology in order to eco-friendly cleaning the air, water, and soil environments.