Recent studies indicate that obesity is linked with several metabolic complications. The cluster of metabolic diseases contributes towards low grade inflammation which leads to metabolic endotoxemia. Metabolic disorders in animals and humans that follow high fat/cholesterol supplementation are associated with alteration of gut microbiota (dysbiosis). Thus diet plays an important role in the management of obesity via maintenance of proper gut microflora. Fermented milks are considered to be functional foods in which lactobacilli drive the fermentation process. The various health benefits of fermented milks are due to the presence of bioactive peptides, branched-chain amino acids and angiotensin-converting enzyme inhibitors. Here we discuss the health promoting effects of fermented milk by different lactobacilli species with a focus on adiposity and inflammatory mechanisms involved in obesity. Further, we discuss the antiobesity effect of milk-fermented dairy products (kefir and yogurt) in animal and clinical studies.