Data help generate knowledge, and more data mean more opportunities to generate knowledge. Advancements in science and technology lead to giant leaps in developing automated and sophisticated high-throughput data generation techniques. All these data are hiding crucial information in plain sight, and they can only be unraveled by asking the right questions. Humans are smart and intelligent creatures; we do have certain limitations when it comes to exploring massive amounts of data. Computers, on the contrary, are relentless. What if we can train these machines to become sensible and intelligent like humans and explore the data? This aspiration of scientists paved the path to the creation of computational tools and AI, integrating human excellence with the untiring computer power to explore the data in possible perspectives. In this chapter we will explore many such approaches and success stories in different domains of synthetic biology that helped further health care.