Conventional disinfection methods for drinking water are imperative in removing harmful pathogens. Then again, they often inadvertently give rise to disinfection by-products (DBPs) that are inherently carcinogenic, posing substantial health risks. Hence, exploring innovative and sustainable solutions to counter the side effects of these classical disinfection techniques is inevitable. This chapter thoroughly investigates the global challenges associated with DBPs in treated drinking water and provides a detailed overview of their prevalence globally. Emphasis has been placed on the prevalence and regulatory frameworks of trihalomethanes (THMs), the most predominant DBP species. Additionally, the chapter delves into examining different sustainable water management strategies aimed at reducing the formation of DBPs in treated drinking water, including source water protection, optimum use of disinfectants, and the implementation of advanced treatment technologies. Special attention is given to reducing THMs and their precursors, highlighting the effectiveness of membrane filtration, green adsorbents, and advanced oxidation processes (AOPs). The importance of integrating these strategies with robust monitoring systems and proactive policy measures to safeguard public health in the long term is also highlighted. Additionally, the chapter underscores the need for continuous research and development of innovative DBP control methods while advocating for a holistic and sustainable approach to drinking water management. Ultimately, this chapter aims to contribute to the ongoing dialogue on protecting public health and ensuring long-term water security by emphasizing sustainable DBP minimization strategies.